ODCs

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1 OMIM reference -
1 associated gene
1 sign/symptom

PROTEIN INTERACTIONS: 1

2 OMIM references -
6 associated genes
14 signs/symptoms

Pancreatic hypoplasia - diabetes - congenital heart disease

Thyroid hypoplasia


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	GATA6	(0.72)	NKX2-1

Citations in the biomedical literature:

Pancreatic hypoplasia - diabetes - congenital heart disease		Thyroid hypoplasia
	Synonym(s): - Yorifuji-Okuno syndrome		Synonym(s): (no synonyms)

	Classification (Orphanet): - Rare endocrine disease - Rare genetic disease		Classification (Orphanet): - Rare endocrine disease - Rare genetic disease

	Classification (ICD10): (no data available)		Classification (ICD10): - Endocrine, nutritional and metabolic diseases -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: variable Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: (no data available)

	External references: 1 OMIM reference - No MeSH references		External references: 2 OMIM references - No MeSH references

Pancreatic hypoplasia - diabetes - congenital heart disease		Thyroid hypoplasia
	Very frequent - Stillbirth / neonatal death		Very frequent - Absent / hypotonic / flaccid abdominal wall muscles - Asthenia / fatigue / weakness - Coarse face - Constipation - Ectopic / agenesis / dysgenesis / hypoplastic thyroid - Face / facial anomalies - Failure to thrive / difficulties for feeding in infancy / growth delay - Hepatitis / icterus / cholestasis - Hypothyroidy - Hypotonia - Large fontanelle / delayed fontanelle closure - Macroglossia / tongue protrusion / proeminent / hypertrophic Frequent - Intellectual deficit / mental / psychomotor retardation / learning disability - Short stature / dwarfism / nanism